WCN23-1071 GENOME-WIDE ASSOCIATION ANALYSIS OF PROTEIN CODING VARIANTS IN IGA NEPHROPATHY
نویسندگان
چکیده
IgA nephropathy (IgAN) is a major cause of kidney failure worldwide. To date, at least 8 GWASs have been performed for IgAN with more than 30 susceptibility loci being discovered. GWAS-implicated variants are generally common that confer relatively small effects and lie within nonprotein-coding sequence, the cumulative these can only explain moderate amount overall risk IgAN. Up to today, few studies systematically evaluated contribution coding variation in
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2023
ISSN: ['2468-0249']
DOI: https://doi.org/10.1016/j.ekir.2023.02.562